Modeling, synthesis and biological activity of novel antifungal agents (1)

T Tsukuda; Y Shiratori; M Watanabe; H Ontsuka; K Hattori; M Shirai; N Shimma

doi:10.1016/s0960-894x(98)00316-3

Modeling, synthesis and biological activity of novel antifungal agents (1)

Bioorg Med Chem Lett. 1998 Jul 21;8(14):1819-24. doi: 10.1016/s0960-894x(98)00316-3.

Authors

T Tsukuda¹, Y Shiratori, M Watanabe, H Ontsuka, K Hattori, M Shirai, N Shimma

Affiliation

¹ Department of Medicinal Chemistry, Nippon Roche Research Center, Kamakura, Japan.

PMID: 9873440
DOI: 10.1016/s0960-894x(98)00316-3

Abstract

Homology modeling of candida lanosterol C-14 demethylase, synthesis and in vitro antifungal activities of cyclohexyl analogs of restricticin are described.

MeSH terms

Amino Acid Sequence
Animals
Antifungal Agents* / chemical synthesis
Antifungal Agents* / chemistry
Antifungal Agents* / pharmacology
Aspergillus fumigatus / drug effects
Candida albicans / drug effects
Cryptococcus neoformans / drug effects
Cytochrome P-450 Enzyme Inhibitors
Microbial Sensitivity Tests
Microsomes, Liver / drug effects
Microsomes, Liver / enzymology
Models, Chemical
Molecular Sequence Data
Oxidoreductases / antagonists & inhibitors
Rats
Sequence Homology, Amino Acid
Sterol 14-Demethylase

Substances

Antifungal Agents
Cytochrome P-450 Enzyme Inhibitors
Oxidoreductases
Sterol 14-Demethylase